Therapeutic Areas

GUARDIAN RESEARCH ORGANIZATION, LLC THERAPEUTIC AREAS FOR CLINICAL TRIALS

Guided by our passion for innovative science, Guardian Research is committed to working with some of the most reputable pharmaceutical, biotechnology, and medical device companies in the world in testing treatment interventions in therapeutic areas where we believe we have an opportunity to make a meaningful difference for patients. Currently, Guardian Research responds to multiple clinical trial opportunities in the following therapeutic areas:

Clinical Trials in Cardiology

Clinical trials on diseases and conditions that affect the structure and function of the heart and blood vessels, including but limited to:

• Acute Coronary Syndrome
• Acute Myocardial Infarction (AMI)
• Aneurysms (cardiac)
• Angina Pectoris
• Anticoagulation
• Aortic Valve Stenosis
• Arrhythmia
• Artherosclerotic Cardiovascular Diseases
• Atrial Fibrillation
• Cardiac Catheterization
• Cardiac Ischemia
• Cardiomyopathies
• Cardiovascular Device

• Cardiovascular Disease (CVD)
• Cholesterol
• Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
• Congestive Heart Failure (CHF)
• Coronary Artery Disease (CAD)
• Coronary Devices
• Critical Limb Ischemia
• Dysrhythmias
• Heart Disorders (other)
• Heart Failure
• Hypertension
• Hypercholesterolemia
• Hypertriglyceridemia

• Infections (CV)
• Myocardial Infarction
• Neoplasms (CV)
• Paroxysmal Supraventricular Tachycardia
• Peripheral Artery Disease
• Shock-pace makers/defib
• Syncope
• Tachycardia
• Thrombus
• Transplants (organs)
• Valvular Heart Disease
• Vascular Disease
• Venous Thromboembolism (VTE)

Clinical Trials in Endocrinology

Clinical trials on diseases and conditions that affect that affect hormone-producing glands such as the pituitary, thyroid, ovary and testis, including but limited to:

∙ Acromegaly
∙ Congenital Adrenal Hyperplasia
∙ Cushing Syndrome
∙ Diabetes Complications
∙ Diabetic Foot Ulcers
∙ Diabetes Mellitus Type 1
∙ Diabetes Mellitus Type 2
∙ Diabetic Nephropathy
∙ Diabetic Peripheral Neuropathy
∙ Endocrine/ Metabolic Syndrome
∙ Endocrine/ Metabolic Neoplasms
∙ Growth Disorders
∙ Hyperlipidemia

∙ Hyperplasia
∙ Hypertriglyceridemia
∙ Hypertriglyceridemia and Atherosclerotic CV
∙ Hypoglycemia
∙ Hypogonadism
∙ Hypoparathyroidism
∙ Lipid Disorders
∙ Nonalcoholic Steatohepatitis (NASH)
∙ Obesity
∙ Diabetic Peripheral Neuropathy
∙ Thyroid Disorders
∙ Triglycerides
∙ Weight Loss

Clinical Trials in Gastroenterology

Clinical trials on diseases and conditions that affect that affect the gastrointestinal organs, including but limited to:

∙ Bowel Cleansing Treatments
∙ Carcinoid Syndrome
∙ Celiac Disease
∙ Chronic Idiopathic Constipation (CIC)
∙ Cirrhosis
∙ Clostridium Difficile (C. diff)
∙ Colon Cleansing
∙ Colonoscopy
∙ Crohn’s Disease
∙ Diarrhea
∙ Esophagitis
∙ Gall Bladder Disorders
∙ Gastroenteritis
∙ Gastroesophageal Reflux Disease (GERD)
∙ Gastroparesis
∙ GI Hemorrhage
∙ GI Infections
∙ GI Neoplasms
∙ GI Ulcers

∙ H. pylori (Helicobacter pylori)
∙ Inflammatory Bowel Disease (IBD)
∙ Irritable Bowel Syndrome (IBS)
∙ Liver Disorders
∙ Malabsorption
∙ Nonalcoholic Fatty Liver Disease (NAFLD)
∙ Nonalcoholic Steatohepatitis (NASH)
∙ Non-Erosive Reflux Disease
∙ Opioid Induced Bowel Dysfunction
∙ Pancreatic Disorders
∙ Pediatric Chronic Idiopathic Constipation (CIC)
∙ Pediatric Crohn’s Disease
∙ Pediatric Ulcerative Colitis
∙ Primary Biliary Cholangitis (PBC)
∙ Progressive Familial Intrahepatic Cholestasis (PFIC)
∙ Short Bowel Syndrome (SBS)
∙ Stomach Disorders
∙ Ulcerative Colitis

Clinical Trials in Infectious Disease

Clinical trials on medical conditions caused by the invasion of a pathogen, including bacteria, viruses, fungi and parasites, including:

∙ Acute Flu
∙ AIDS
∙ Bacterial
∙ Body Myositis
∙ Chlamydia
∙ Clostridium Difficile (C-diff)
∙ Community Acquired Pneumonia
∙ Coronavirus (COVID-19)
∙ Cytomegalovirus
∙ E. Coli
∙ Gonorrhea
∙ Hepatitis
∙ Herpes Simplex Labialis (Cold Sore)
∙ Herpes Simplex-2

∙ HIV
∙ Hospital Acquired Pneumonia
∙ Human Papilloma Virus (HPV)
∙ Influenza
∙ Lyme Disease
∙ Monkeypox
∙ Oropharyngeal Candidiasis
∙ Pneumonia
∙ Respiratory Syncytial Virus (RSV)
∙ Scabies
∙ Shingles
∙ Staph infection
∙ Streptococcus
∙ Syphilis
∙ Viral Infections

Clinical Trials in Nephrology

Clinical trials on diseases and conditions that affect the kidneys and urinary tract, including but limited to:

∙ Acute Kidney Injury (AKI)
∙ Autosomal Dominant Polycystic Kidney Disease
∙ Chronic Kidney Disease
∙ Complement-Mediated Glomerular Disease
∙ Diabetic Kidney Disease
∙ Diabetic Nephropathy
∙ End Stage Renal Disease
∙ Focal Segmental Glomerulosclerosis (FSGS)

∙ Hyperkalemia
∙ IgA Nephropathy
∙ Immunoglobulin A Nephropathy
∙ Kidney Disease
∙ Kidney Failure
∙ Lupus Nephritis
∙ Renal Failure
∙ Systemic Lupus Erthrymatosus (SLE)
∙ Wilson’s Disease

Clinical Trials in Neurology

Clinical trials on diseases and conditions that affect the neurological system, including but limited to:

∙ Adolescent Migraine
∙ Alzheimer’s
∙ Analgesia
∙ Angelman Syndrome
∙ Brain Aneurysm
∙ Brain Disorders
∙ Brain Injuries
∙ Cerebral Palsy
∙ Concussions
∙ Dementia
∙ Epilepsy
∙ Focal Onset Epilepsy
∙ Essential Tremors
∙ Restless Leg Syndrome
∙ Headaches
∙ Inflammatory Diseases

∙ Migraine Headaches
∙ Mild Cognitive Impairment
∙ Multiple Sclerosis
∙ Multiple Sclerosis Spasticity
∙ Relapsing MS
∙ Myotonic Dystrophy
∙ Myasthenia Gravis
∙ Neuropathy
∙ Post Herpetic Neuralgia
∙ Parkinson’s Disease
∙ Seizures
∙ Spinal Cord Injuries
∙ Stroke
∙ Stroke – Acute Ischemic
∙ Tardive Dyskinesia
∙ Tourette’s
∙ Other

Clinical Trials in Pulmonology

Clinical trials on diseases and conditions that affect the respiratory system, including but limited to:

∙ Acute Bronchospasm
∙ Acute Respiratory Distress Syndrome (ARDS)
∙ Adolescent Asthma
∙ Asthma
∙ Bronchiectasis
∙ Bronchitis
∙ Chronic Cough
∙ Chronic Obstructive Pulmonary Disease (COPD)
∙ Cystic Fibrosis
∙ Emphysema
∙ Eosinophilic Asthma
∙ Idiopathic Pulmonary Fibrosis (IPF)
∙ Laryngitis
∙ Non-Cystic Fibrosis Bronchiectasis
∙ Nontuberculous Mycobacteria (NTM)

∙ Pediatric Asthma
∙ Pneumonia
∙ Pulmonary Arterial Hypertension
∙ Pulmonary Fibrosis
∙ Pulmonary Hypertension
∙ Pulmonary Sarcoidosis
∙ Respiratory Infections
∙ Refractory Chronic Cough
∙ Respiratory Infections
∙ Respiratory Syncytial Virus (RSV)
∙ Respiratory Tract Infection
∙ Rhinitis
∙ Sarcoid-Associated Pulmonary Hypertension (SAPH)
∙ Sinusitis
∙ Tonsilitis

Clinical Trials in Rheumatology

Clinical trials on diseases and conditions that affect the joints, muscles, and bones, including but limited to:

∙ Adhesive Capsulitis (Frozen Shoulder)
∙ Ankylosing Spondylitis
∙ Arthritis
∙ Axial Spondyloarthritis
∙ Cutaneous Lupus Erythematous
∙ Fibromyalgia
∙ Gout

∙ Lupus
∙ Myasthenia Gravis
∙ Osteoarthritis
∙ Rheumatoid Arthritis
∙ Sjogren’s Syndrome
∙ Spondyloarthritis
∙ Systemic Lupus Erythematosus (SLE)